Blood-C, is a 2011 anime/manga series and 2012 film produced and collaborated by Studio Production I.G and manga creators CLAMP. This is Production I.G's second anime series related to the Blood franchise, the first being Blood+, which aired in 2005–2006.
Saya Kisaragi is an overly clumsy teenage girl as well as a kind student at Sanbara Academy; when not in school she spends time with her friends at a local cafe. She lives with her father, Tadayoshi Kisaragi within a shrine called Ukishima Shrine, in a quiet and oddly almost deserted village. At night, she protects her village by hunting and killing things known as the Old Ones. Possessing supernatural abilities, the Old Ones prey on humans, and only Saya has the ability to defeat them. When she is faced with various forms of 'trials' that test her kindness, it brings misfortune for being 'overly-kind'. Against adversity and for the sake of her friends, she maintains her kind heart and wishes to become stronger. Why is she being tested? And what path will Saya’s life take in a place where not everything or everyone is as they seem?
The anime was announced in the May 2011 issue of Shōnen Ace magazine where it was revealed it will be a collaboration between Studio Production I.G and the manga creator group CLAMP where CLAMP will be creating the story and original character designs while Production I.G will be handling the animation. The anime is published by Aniplex and will be directed by Tsutomu Mizushima with Junichi Fujisaku, who previously worked on Blood the Last Vampire and Blood+, as creative supervisor. Nanase Ohkawa will be supervising the scripts and co-writing them with Fujisaku while Kazuchika Kise is adapting CLAMP's character designs for animation and Naoki Sato is composing the music. The opening theme is "spiral" performed by Ray Fujita's band DUSTZ. The anime began airing on July 8, 2011 on MBS and TBS.